Analysis of 25I-NBOMe, 25B-NBOMe, 25C-NBOMe and other dimethoxyphenyl-N-[(2-methoxyphenyl) methyl]ethanamine derivatives on blotter paper,25c-nbome is an analytical reference standard that is structurally categorized as a phenethylamine erowid,25c-nbome vs 25i,synthesis,hyperreal


2C-NBOMe is an analytical reference standard that is structurally categorized as a phenethylamine. It is a derivative of 2C-C having an N-(2-methoxybenzyl) addition at the amine.25c-NBOMe Erowid,25c-NBOMe vs 25i, synthesis, hyperreal

2C-C is a known hallucinogen that stimulates monoamine receptor activity and inhibits the re-uptake of serotonin and norepinephrine in rat brain synaptosomes (IC50 = 31 and 63 M, respectively).

The N-(2-methoxybenzyl) addition to 2C-NBOMe increases the affinity and selectivity for the 5-HT2A receptor over other serotonin receptors.

Radiolabeled it has been used for positron emission tomography imaging of the 5-HT2A receptor in the porcine brain.4 This product is intended for forensic and research uses.

In recent years, N-methoxybenzyl-methoxyphenylethylamine (NBOMe) derivatives, a class of designer hallucinogenic drugs, have become popular drugs of abuse.

These drugs have been the cause of severe intoxications and even deaths.

They act as 5-HT2A receptor agonists and have been reported to produce serotonin-like syndrome with bizarre behavior, severe agitation, and seizures persisting for as long as 3 days.

The most commonly reported derivatives are 25I-NBOMe, 25B-NBOMe and 25C-NBOMe, respectively 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl) methyl]ethanamine, N-(2-methoxybenzyl)-2,5-dimethoxy-4-bromophenethylamine and N-(2-methoxybenzyl)-2,5-dimethoxy-4-chlorophenethylamine.

Like many low-dose hallucinogenic drugs, these compounds are often sold on blotter paper.25c-NBOMe Erowid,25c-NBOMe vs 25i, synthesis, hyperreal

Three different types of commercially available blotter papers reported containing NBOMe derivatives were obtained.

These blotter papers were screened using Direct Analysis in Real-Time AccuTOFTM mass spectrometry followed by confirmation and quantification by high-performance liquid chromatography triple quadrupole mass spectrometry.

The major drug present on each of the three blotter products was different, 25I-NBOMe,25B-NBOMe.
The blotter papers were also found to have minute amounts of two or three NBOMe derivative impurities of 25H-NBOMe, 25I-NBOMe, 25B-NBOMe, or 25D-NBOMe.

Technical Information
Formal Name
2-(4-chloro-2,5-dimethoxy phenyl)-N-(2-methoxybenzyl) ethanamine, monohydrochloride
CAS Number
Molecular Formula
C18H22ClNO3 HCl
Formula Weight
Purity: 98%
A crystalline solid: max
205, 295 nm
InChi Code
InChi Key
DEA Schedule I
Shipping & Storage Information
Storage: -20C
Room Temperature in continental US; may vary elsewhere
Stabilit: 2 years

Additional information

Weight N/A
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