AM630

Description

AM-630(6-Iodopravadoline) is a drug that acts as a potent and selective inverse agonist for the cannabinoid receptor CB₂, with a K_i of 32.1 nM at CB₂ and 165x selectivity over CB₁, at which it acted as a weak partial agonist.AM-630,human cannabinoid receptor 2,cnr2,indole cannabinoids,cb2 ligands,cb2 receptor discovery

It is used in the study of CB₂ mediated responses and has been used to investigate the possible role of CB₂ receptors in the brain.UR-144

AM-630 is significant as one of the first indole derived cannabinoid ligands substituted on the 6-position of the indole ring, a position that has subsequently been found to be important in determining affinity and efficacy at both the CB₁ and CB₂ receptors, and has led to the development of many related derivatives

Cannabinoids produce biochemical and pharmacological effects by interacting with the central cannabinoid (CB₁) and peripheral cannabinoid (CB₂) G protein-coupled receptors.6-Iodopravadoline

AM630 is a selective CB₂ receptor antagonist that binds to CB₁ and CB₂ receptors with K_i values of 5.2 M and 31.2 nM, respectively.cnr2

AM630 behaves as an inverse agonist at CB₂ receptors, attenuating the antinociceptive effects of a number of cannabinoids, and as a weak partial agonist at CB₁ receptors. ^1,2,3.

6-Iodopravadoline,AM-630,human cannabinoid receptor 2,cnr2,indole cannabinoids,cb2 ligands,cb2 receptor discovery, a drug that acts as a potent and selective

CAS Number:164178-33-0
Chemical and physical data
Formula C23H25IN2O3
Molar mass 504.360 g/mol

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