AM-630(6-Iodopravadoline) is a drug that acts as a potent and selective inverse agonist for the cannabinoid receptor CB2, with a Ki of 32.1 nM at CB2 and 165x selectivity over CB1, at which it acted as a weak partial agonist.AM-630,human cannabinoid receptor 2,cnr2,indole cannabinoids,cb2 ligands,cb2 receptor discovery
It is used in the study of CB2 mediated responses and has been used to investigate the possible role of CB2 receptors in the brain.UR-144
AM-630 is significant as one of the first indole derived cannabinoid ligands substituted on the 6-position of the indole ring, a position that has subsequently been found to be important in determining affinity and efficacy at both the CB1 and CB2 receptors, and has led to the development of many related derivatives
Cannabinoids produce biochemical and pharmacological effects by interacting with the central cannabinoid (CB1) and peripheral cannabinoid (CB2) G protein-coupled receptors.6-Iodopravadoline
AM630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors with Ki values of 5.2 M and 31.2 nM, respectively.cnr2
AM630 behaves as an inverse agonist at CB2 receptors, attenuating the antinociceptive effects of a number of cannabinoids, and as a weak partial agonist at CB1 receptors. 1,2,3.
6-Iodopravadoline,AM-630,human cannabinoid receptor 2,cnr2,indole cannabinoids,cb2 ligands,cb2 receptor discovery, a drug that acts as a potent and selective
Chemical and physical data
Molar mass 504.360 g/mol
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