Mexedrone�(3-methoxy-2-(methylamino)-1-(p-tolyl)propan-1-one�also known as�4-MMC-MeO) is a putative�stimulant�and possible�euphoriant�of the�cathinone�chemical class with a potency of roughly 1/10th of that of�mephedrone.mexedrone crystal effects,mexedrone erowid,n-isobutyl-hexedrone,4mmc erowid,
This compound has little to no history of human usage prior to its release in August 2015 as a newly available grey area research chemical.
�It has been primarily marketed as a legal alternative to�mephedrone�although anecdotal reports seem to universally suggest that it is largely inferior in its recreational effects due to its weaker potency, lack of�stimulation�and�euphoria.
It may have been developed as a result of another much more effective, but problematic mephedrone derivative, N-methoxymephedrone.
Mexedrone acts as a�releasing agent�of�serotonin�and a�reuptake inhibitor�for monoamine�neurotransmitters�serotonin,�dopamine�and�noradrenaline
. Despite its chemical similarity to�mephedrone, it lacks the dopamine and noradrenaline releasing properties, and is approximately 10-20x weaker in its reuptake inhibiting and serotonin releasing properties.
This increase in neurotransmitters provides an explanation for the�euphoric�and anecdotal�stimulating�effects induced by this experience.mexedrone crystal effects,mexedrone erowid,n-isobutyl-hexedrone,4mmc erowid,
The serotonergic activity with lack of significant dopaminergic and noradrenergic activity is similar to that of�MDAI�and consistent with usage reports that often state that mexedrone is more sedating than stimulating.
Due to the much lower potency (1/7 to 1/20th at different monoamine transporters) compared to mephedrone, considerably higher doses are required to achieve noticeable effects.ETHYLPHENIDATE